Journal
FRONTIERS IN PHYSIOLOGY
Volume 2, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2011.00014
Keywords
monodomain model; personalized health care; strong scalability
Categories
Funding
- Office of Science and Technology through EPSRC's High End Computing Programme
- Austrian Science Fund FWF [F3210-N18]
- NAG Ltd.
- EPSRC [EP/F043929/1]
- EPSRC [EP/H046410/1] Funding Source: UKRI
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL101196] Funding Source: NIH RePORTER
- Austrian Science Fund (FWF) [F 3201] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H019898/1, EP/F043929/1, EP/H046410/1] Funding Source: researchfish
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In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
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