Journal
FRONTIERS IN PHYSIOLOGY
Volume 1, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2010.00156
Keywords
necrosis; mitochondria; RIP kinases; PARP; reactive oxygen species
Categories
Funding
- National Institutes of Health [HL092327, HL094404, HL052490]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094404] Funding Source: NIH RePORTER
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In contrast to the programmed nature of apoptosis and autophagy, necrotic cell death has always been believed to be a random, uncontrolled process that leads to the accidental death of the cell. This dogma, however, is being challenged and the concept of necrosis also being programmed is gaining ground. In particular, mitochondria appear to play a pivotal role in the mediation of programmed necrosis. The purpose of this review, therefore, is to appraise the current concepts regarding the signaling mechanisms of programmed necrosis, with specific attention to the contribution of mitochondria to this process.
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