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Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs
Anne T. Nies et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions
John D. Clarke et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Renal drug-drug interactions: what we have learned and where we are going
Eve-Irene Lepist et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development
Yurong Lai et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma
Raphael Marechal et al.
GASTROENTEROLOGY (2012)
Pharmacogenomics of adverse drug reactions: implementing personalized medicine
Chun-Yu Wei et al.
HUMAN MOLECULAR GENETICS (2012)
Drug transport across the blood-brain barrier
William M. Pardridge
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)
6-mercaptopurine transport in human lymphocytes: Correlation with drug-induced cytotoxicity
Laurie S. Conklin et al.
JOURNAL OF DIGESTIVE DISEASES (2012)
Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy
Yasuhiro Murata et al.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2012)
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
Jeffrey A. Pfefferkorn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Relating Molecular Properties and in Vitro Assay Results to in Vivo Drug Disposition and Toxicity Outcomes
Jeffrey J. Sutherland et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions
Maria Karlgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
An in vivo role of Mrp2 in the rat hepatocytes by immunocytochemistry for amoxicillin using the transporter-deficient EHBR
Kunio Fujiwara et al.
JOURNAL OF MOLECULAR HISTOLOGY (2012)
Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters
Toshiyuki Takanohashi et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2012)
Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions
Anne Sophie Grandvuinet et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2012)
Local Lipid Reorganization by a Transmembrane Protein Domain
Heidi Koldso et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2012)
From mosaic to patchwork: Matching lipids and proteins in membrane organization
Nikola S. Mueller et al.
MOLECULAR MEMBRANE BIOLOGY (2012)
Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3
Britta Haenisch et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2012)
Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)
Ivano Moschen et al.
NEUROCHEMICAL RESEARCH (2012)
Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation
Miguel C. Teixeira et al.
MICROBIAL CELL FACTORIES (2012)
ROLE OF HUMAN NUCLEOSIDE TRANSPORTERS IN THE UPTAKE AND CYTOTOXICITY OF AZACITIDINE AND DECITABINE
Vijaya L. Damaraju et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2012)
Adverse Drug Reactions in Children-A Systematic Review
Rebecca Mary Diane Smyth et al.
PLOS ONE (2012)
A Steered Molecular Dynamics Study of Binding and Translocation Processes in the GABA Transporter
Soren Skovstrup et al.
PLOS ONE (2012)
Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions
Manthena V. S. Varma et al.
PHARMACEUTICAL RESEARCH (2012)
Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis
Ana Miguel et al.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2012)
Refinement of protein structure homology models via long, all-atom molecular dynamics simulations
Alpan Raval et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2012)
Pharmacogenomics and Patient Care: One Size Does Not Fit All
K. M. Giacomini et al.
Science Translational Medicine (2012)
Epistemic and methodological iteration in scientific research
Kevin C. Elliott
STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE (2012)
Mass spectrometry imaging is moving toward drug protein co-localization
Rima Ait-Belkacem et al.
TRENDS IN BIOTECHNOLOGY (2012)
A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds
Hongming Chen et al.
MEDCHEMCOMM (2012)
Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
Gyorgy Marko-Varga et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2012)
Organic Anion Transporters and Their Implications in Pharmacotherapy
Arian Emami Riedmaier et al.
PHARMACOLOGICAL REVIEWS (2012)
In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
Yi-an Bi et al.
DRUG METABOLISM AND DISPOSITION (2012)
The TM2 6′ Position of GABAA Receptors Mediates Alcohol Inhibition
W. David Johnson et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
BDDCS Applied to Over 900 Drugs
Leslie Z. Benet et al.
AAPS JOURNAL (2011)
Alcohol-Binding Sites in Distinct Brain Proteins: The Quest for Atomic Level Resolution
Rebecca J. Howard et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2011)
Association of Intergenic Polymorphism of Organic Anion Transporter 1 and 3 Genes With Hypertension and Blood Pressure Response to Hydrochlorothiazide
Yun-Feng Han et al.
AMERICAN JOURNAL OF HYPERTENSION (2011)
Mass spectrometry imaging with high resolution in mass and space (HR2 MSI) for reliable investigation of drug compound distributions on the cellular level
Andreas Roempp et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2011)
Pharmacogenetics of Drug Metabolizing Enzymes and Transporters: Effects on Pharmacokinetics and Pharmacodynamics of Anticancer Agents
Norman H. Lee
Anti-Cancer Agents in Medicinal Chemistry (2011)
Immunocytochemistry for Amoxicillin and Its Use for Studying Uptake of the Drug in the Intestine, Liver, and Kidney of Rats
Kunio Fujiwara et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Role of Transporters in Drug Interactions
Hyo-Kyung Han
ARCHIVES OF PHARMACAL RESEARCH (2011)
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors
Yeeman K. Ramtohul et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy
David A. Powell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution
Jeffrey A. Pfefferkorn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Membrane Interface Composition Drives the Structure and the Tilt of the Single Transmembrane Helix Protein PMP1: MD Studies
Veronica Beswick et al.
BIOPHYSICAL JOURNAL (2011)
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast
Karin Lanthaler et al.
BMC BIOLOGY (2011)
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
Atsushi Yonezawa et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells
Yangzom D. Bhutia et al.
CANCER RESEARCH (2011)
Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
Takahito Nakahara et al.
CANCER SCIENCE (2011)
Cytochromes P450 as useful biocatalysts: addressing the limitations
Elaine O'Reilly et al.
CHEMICAL COMMUNICATIONS (2011)
Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins
Ken-ichi Hosoya et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2011)
Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study
L. A. Donnelly et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
A New Trend in Personalized Medicine: Rapid Detection of SNPs in Drug Transporter Genes by the SmartAmp Method
W. Aw et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Transporter-Mediated Drug-Drug Interactions
L. Zhang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Transporter-Mediated Drug Uptake and Efflux: Important Determinants of Adverse Drug Reactions
O. Zolk et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels Predict Response to Gemcitabine in Patients With Biliary Tract Cancer (BTC)
D. Santini et al.
CURRENT CANCER DRUG TARGETS (2011)
In-Silico ADME Models: A General Assessment of their Utility in Drug Discovery Applications
M. Paul Gleeson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain
Fiona E. Parkinson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Pharmacogenetics: past, present and future
Munir Pirmohamed
DRUG DISCOVERY TODAY (2011)
Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
Douglas B. Kell et al.
DRUG DISCOVERY TODAY (2011)
Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant
Sabrina Pagliarusco et al.
DRUG METABOLISM AND DISPOSITION (2011)
Clinical Importance of OATP1B1 and OATP1B3 in Drug-Drug Interactions
Yoshihisa Shitara
DRUG METABOLISM AND PHARMACOKINETICS (2011)
Clinical Implications of Pharmacogenetic Variation on the Effects of Statins
Simran D. S. Maggo et al.
DRUG SAFETY (2011)
Pharmacogenomics and adverse drug reactions: the case of statins
Mariano A. Giorgi et al.
EXPERT OPINION ON PHARMACOTHERAPY (2011)
Drug-permeability and transporter assays in Caco-2 and MDCK cell lines
Donna A. Volpe
FUTURE MEDICINAL CHEMISTRY (2011)
OVERCOMING COMMUNICATION LATENCY BARRIERS IN MASSIVELY PARALLEL SCIENTIFIC COMPUTATION
Ron O. Dror et al.
IEEE MICRO (2011)
Role of Dihydrolipoamide Dehydrogenase in Regulation of Raffinose Transport in Streptococcus pneumoniae
Robert E. Tyx et al.
JOURNAL OF BACTERIOLOGY (2011)
Deletion of Multispecific Organic Anion Transporter Oat1/Slc22a6 Protects against Mercury-induced Kidney Injury
Adriana M. Torres et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Characterizing the Diversity and Biological Relevance of the MLPCN Assay Manifold and Screening Set
Jintao Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Profiling of a Prescription Drug Library for Potential Renal Drug-Drug Interactions Mediated by the Organic Cation Transporter 2
Yasuto Kido et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Renata M. Oballa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
Yasuo Uchida et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Quantitative Targeted Absolute Proteomics-Based ADME Research as a New Path to Drug Discovery and Development: Methodology, Advantages, Strategy, and Prospects
Sumio Ohtsuki et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging
Gyoergy Marko-Varga et al.
JOURNAL OF PROTEOMICS (2011)
Proteomics Profiling of Madin-Darby Canine Kidney Plasma Membranes Reveals Wnt-5a Involvement during Oncogenic H-Ras/TGF-β-mediated Epithelial-Mesenchymal Transition
Yuan-Shou Chen et al.
MOLECULAR & CELLULAR PROTEOMICS (2011)
Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH
Kathleen M. Carroll et al.
MOLECULAR & CELLULAR PROTEOMICS (2011)
pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1
Manthena V. Varma et al.
MOLECULAR PHARMACEUTICS (2011)
Engineering microbial biofuel tolerance and export using efflux pumps
Mary J. Dunlop et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Controlled Translocation of Individual DNA Molecules through Protein Nanopores with Engineered Molecular Brakes
Marcela Rincon-Restrepo et al.
NANO LETTERS (2011)
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Hugues Nury et al.
NATURE (2011)
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing
Jan E. Carette et al.
NATURE BIOTECHNOLOGY (2011)
TRIAL WATCH Phase III and submission failures: 2007-2010
John Arrowsmith
NATURE REVIEWS DRUG DISCOVERY (2011)
Understanding and Classifying Metabolite Space and Metabolite-Likeness
Julio E. Peironcely et al.
PLOS ONE (2011)
The BCS, BDDCS, and Regulatory Guidances
Mei-Ling Chen et al.
PHARMACEUTICAL RESEARCH (2011)
Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
Piet H. van der Graaf et al.
PHARMACEUTICAL RESEARCH (2011)
Pharmacogenetics of drug transporters in the enterohepatic circulation
Bruno Stieger et al.
PHARMACOGENOMICS (2011)
Transporter-mediated drug-drug interactions
Fabian Mueller et al.
PHARMACOGENOMICS (2011)
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
Rebecca J. Howard et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Knocking out the door to tunicamycin entry
Michael C. Bassik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin
Jan H. Reiling et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy
Philip Brownridge et al.
PROTEOMICS (2011)
How Fast-Folding Proteins Fold
Kresten Lindorff-Larsen et al.
SCIENCE (2011)
Cell Membranes: The Lipid Perspective
Uenal Coskun et al.
STRUCTURE (2011)
Molecular Simulation Approaches to Membrane Proteins
Phillip J. Stansfeld et al.
STRUCTURE (2011)
Transporter mediated uptake and efflux of antiretroviral drugs: Potential for drug-drug interactions
Zoe Riches et al.
TOXICOLOGY (2011)
Hierarchical mesoscale domain organization of the plasma membrane
Akihiro Kusumi et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
Biological membranes: the importance of molecular detail
Anthony G. Lee
TRENDS IN BIOCHEMICAL SCIENCES (2011)
Emerging role for drug transporters at the blood-testis barrier
Dolores D. Mruk et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2011)
MALDI imaging mass spectrometry: bridging biology and chemistry in drug development
Stephen Castellino et al.
BIOANALYSIS (2011)
Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
MEDCHEMCOMM (2011)
Making sure there's a "give" associated with the "take": producing and using open-source software in big pharma
Gregory Landrum et al.
Journal of Cheminformatics (2011)
Structural diversity of biologically interesting datasets: a scaffold analysis approach
Varun Khanna et al.
JOURNAL OF CHEMINFORMATICS (2011)
Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs
Sabine Klatt et al.
Pharmaceutics (2011)
Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders
Masanori Tachikawa et al.
FLUIDS AND BARRIERS OF THE CNS (2011)
Role of fatty acid transporters in epidermis Implications for health and disease
Denis Khnykin et al.
DERMATO-ENDOCRINOLOGY (2011)
Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice
Yasuo Uchida et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging
Andreas Roempp et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
Olga Khersonsky et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes
Tomomi Furihata et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System
Leslie Z. Benet
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2010)
Molecular signatures-based prediction of enzyme promiscuity
Pablo Carbonell et al.
BIOINFORMATICS (2010)
Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human
Masanobu Sato et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
Stereoselective Transport and Uptake of Propranolol Across Human Intestinal Caco-2 Cell Monolayers
Yi Wang et al.
CHIRALITY (2010)
Evaluation of Drug Transporter Interactions in Drug Discovery and Development
Yurong Lai et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2010)
Rational approaches to targeted polypharmacology: creating and navigating protein-ligand interaction networks
James T. Metz et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Pharmacogenetics of Drug Transporters
R. M. Franke et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant
Tsuyoshi Minematsu et al.
DRUG METABOLISM AND DISPOSITION (2010)
Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
Lidia Miraglia et al.
DRUG METABOLISM AND DISPOSITION (2010)
Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers
Masahiro Tohkin et al.
DRUG METABOLISM AND PHARMACOKINETICS (2010)
Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects
Christina Fahrmayr et al.
DRUG METABOLISM REVIEWS (2010)
Escherichia coli mar and acrAB Mutants Display No Tolerance to Simple Alcohols
Jonas Ankarloo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2010)
Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4
Edward J. Bertaccini et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
Best Practices for QSAR Model Development, Validation, and Exploitation
Alexander Tropsha
MOLECULAR INFORMATICS (2010)
Alcohol- and Alcohol Antagonist-Sensitive Human GABAA Receptors: Tracking δ Subunit Incorporation into Functional Receptors
Pratap Meera et al.
MOLECULAR PHARMACOLOGY (2010)
Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
Neils B. Quashie et al.
MALARIA JOURNAL (2010)
Membrane transporters in drug development
Kathleen M. Giacomini et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity
M. Molina-Arcas et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2010)
Exploring Transmembrane Diffusion Pathways With Molecular Dynamics
Yi Wang et al.
PHYSIOLOGY (2010)
Hijacking Solute Carriers for Proton-Coupled Drug Transport
Catriona M. H. Anderson et al.
PHYSIOLOGY (2010)
Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry
Anna Nilsson et al.
PLOS ONE (2010)
Pharmacogenomics and adverse drug reactions
Shashi Amur et al.
PERSONALIZED MEDICINE (2010)
Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform
Tristan M. Sissung et al.
PHARMACOGENOMICS (2010)
Drug transporter pharmacogenetics in nucleoside-based therapies
Ekaitz Errasti-Murugarren et al.
PHARMACOGENOMICS (2010)
Molecular dynamics of leucine and dopamine transporter proteins in a model cell membrane lipid bilayer
Patrick C. Gedeon et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Organic cation transporter pharmacogenomics and drug-drug interaction
Anne T. Nies et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2010)
Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells
Wolfgang Hagmann et al.
NEOPLASIA (2010)
Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection
Robert Dickinson et al.
CRITICAL CARE (2010)
Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World's Top Oral Drugs
Arik Dahan et al.
AAPS JOURNAL (2009)
Genome-Wide Identification of Saccharomyces cerevisiae Genes Required for Maximal Tolerance to Ethanol
Miguel C. Teixeira et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)
Adverse drug reactions in childhood: a review of prospective studies and safety alerts
A. Clavenna et al.
ARCHIVES OF DISEASE IN CHILDHOOD (2009)
Physiochemical property space distribution among human metabolites, drugs and toxins
Varun Khanna et al.
BMC BIOINFORMATICS (2009)
Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma
Raphael Marechal et al.
CLINICAL CANCER RESEARCH (2009)
Molecular dynamics simulations of membrane channels and transporters
Fatemeh Khalili-Araghi et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
Implications of the Dominant Role of Transporters in Drug Uptake by Cells
Paul D. Dobson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study
Kaixin Zhou et al.
DIABETES (2009)
'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
Paul D. Dobson et al.
DRUG DISCOVERY TODAY (2009)
High-Affinity Interaction of Sartans with H+/Peptide Transporters
Ilka Knuetter et al.
DRUG METABOLISM AND DISPOSITION (2009)
Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
Tsuyoshi Minematsu et al.
DRUG METABOLISM AND DISPOSITION (2009)
The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
Soichiro Matsushima et al.
DRUG METABOLISM AND DISPOSITION (2009)
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
Xin Ming et al.
DRUG METABOLISM AND DISPOSITION (2009)
Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs
Gustav Ahlin et al.
DRUG METABOLISM AND DISPOSITION (2009)
Systems Biology: The elements and principles of Life
Hans V. Westerhoff et al.
FEBS LETTERS (2009)
Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer
James J. Farrell et al.
GASTROENTEROLOGY (2009)
Multicenter Phase II Trial of YM155, a Small-Molecule Suppressor of Survivin, in Patients With Advanced, Refractory, Non-Small-Cell Lung Cancer
Giuseppe Giaccone et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Involvement of Influx and Efflux Transport Systems in Gastrointestinal Absorption of Celiprolol
Yukio Kato et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
The Role of the Equilibrative Nucleoside Transporter 1 (ENT1) in Transport and Metabolism of Ribavirin by Human and Wild-Type or Ent1(-/-) Mouse Erythrocytes
Christopher J. Endres et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice
Christopher J. Endres et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
Masahiro Tsuda et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
The SLCO1B1*5 Genetic Variant Is Associated With Statin-Induced Side Effects
Deepak Voora et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Protein promiscuity and its implications for biotechnology
Irene Nobeli et al.
NATURE BIOTECHNOLOGY (2009)
Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes
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