Journal
FRONTIERS IN PHARMACOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2014.00144
Keywords
CaMKII; calcium channel; calcium current inactivation; calcium current facilitation; calcium current staircase
Categories
Funding
- NIH [R37-HL30077, R01-HL105242, P01-HL80101]
- Fondation Leducq Transatlantic CaMKII Alliance
- American Heart Association
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The cardiac voltage gated Ca2+ current (I-Ca) is critical to the electrophysiological properties, excitation-contraction coupling, mitochondrial energetics, and transcriptional regulation in heart. Thus, it is not surprising that cardiac I-Ca is regulated by numerous pathways. This review will focus on changes in I-Ca that occur during the cardiac action potential (AP), with particular attention to Ca2+-dependent inactivation (CDI), Ca2+-dependent facilitation (CDF) and how calmodulin (CaM) and Ca2+-CaM dependent protein kinase (CaMKII) participate in the regulation of Ca2+ current during the cardiac AP CDI depends on CaM pre-bound to the C-terminal of the L-type Ca2+ channel, such that Ca2+ influx and Ca2+ released from the sarcoplasmic reticulum bind to that CaM and cause CDI. In cardiac myocytes CDI normally pre-dominates over voltage-dependent inactivation. The decrease in I-Ca via CDI provides direct negative feedback on the overall Ca2+ influx during a single beat, when myocyte Ca2+ loading is high. CDF builds up over several beats, depends on CaMKII-dependent Ca2+ channel phosphorylation, and results in a staircase of increasing I-Ca peak, with progressively slower inactivation. CDF and CDI co-exist and in combination may fine-tune the I-Ca waveform during the cardiac AP CDF may partially compensate for the tendency for Ca2+ channel availability to decrease at higher heart rates because of accumulating inactivation. CDF may also allow some reactivation of I-Ca during long duration cardiac APs, and contribute to early afterdepolarizations, a form of triggered arrhythmias.
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