Journal
FRONTIERS IN PHARMACOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2012.00138
Keywords
Alzheimer's disease; CNS immunosenescence; impaired neuronal protection; microglial cells; microglial senescence; neurodegeneration; neuropathological features; neuroprotection
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This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute toward the development of characteristic neuropathological features that characterize Alzheimer's disease. The conceptual framework guiding our thinking is provided by the hypothesis that microglial senescence accounts for impaired neuronal protection and consequent neurodegeneration.
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