Journal
FRONTIERS IN PHARMACOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2012.00127
Keywords
irritable bowel syndrome; brain-gut axis; pathophysiology; autonomic nervous system; hypothalamopituitary-adrenal axis
Categories
Funding
- Deutsche Forschungsgemeinschaft [STO 645/6-1]
- Iuventus Plus program of the Polish Ministry of Science and Higher Education [0119/IP1/2011/71]
Ask authors/readers for more resources
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with an estimated prevalence of 10-20%. Current understanding of the pathophysiology of IBS is incomplete due to the lack of a clearly identified pathological abnormality and due to the lack of reliable biomarkers. Possible mechanisms believed to contribute to IBS development and IBS like symptoms include physical stressors, such as infection or inflammation, psychological, and environmental factors, like anxiety, depression, and significant negative life events. Some of these mechanisms may involve the brain-gut axis (BGA). In this article we review the current knowledge on the possible involvement of the BGA in IBS and discuss new directions for potential future therapies of IBS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available