Journal
FRONTIERS IN NEUROSCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnins.2014.00071
Keywords
adult neurogenesis; neuroligin-1; cell survival; dendritic spine; synaptogenesis; dendritic growth
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Funding
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development CDA-2 award [NIH NS26494, MH046613, UL1TR000128, P30NS061800]
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Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.
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