Journal
FRONTIERS IN NEUROSCIENCE
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/neuro.15.003.2009
Keywords
recombinant inbred mice; hippocampus; QTL; genetical genomics; transcript expression
Categories
Funding
- Volkswagenstiftung [U01AA13499, U24AA13513, U01-AA014425]
- Lookout Foundation
- McDonnell Foundation
- Picower Foundation
- NIH [1U01 AA13515, P20MH062009, U01CA105417, R01 NS049445-01, P20]
- NIAAA INIA [AA013503, U01AA013515]
- MRC [G0000170]
- BSIK [03053]
- NIAAA [U01AA13499, U24AA13513]
- NIDA/NIMH/NIAAA [P20-DA 21131]
- NCI MMHCC [U01CA105417]
- NCRR [U24 RR021760]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS052397] Funding Source: NIH RePORTER
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Differences in gene expression in the CNS influence behavior and disease susceptibility. To systematically explore the role of normal variation in expression on hippocampal structure and function, we generated an online microarray database for a diverse panel of strains of mice, including most common inbred strains and numerous recombinant inbred lines (www.genenetwork.org). Using this resource, coexpression networks for families of genes can be generated rapidly to test causal models related to function. The data set is optimized for quantitative trait locus (QTL) mapping and was used to identify over 5500 QTLs that modulate mRNA levels. We describe a wide variety of analyses and novel synthetic approaches that take advantage of this resource, and demonstrate how both the data and associated tools can be applied to the study of gene regulation in the hippocampus and relations to structure and function.
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