Journal
FEBS OPEN BIO
Volume 4, Issue -, Pages 162-167Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.fob.2014.01.008
Keywords
Alzheimer's disease; A beta; BACE1; Rice grain; IP6; SH-SY5Y cells
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Funding
- Niigata University Research Projects
- Japan Science and Technology Agency
- Japan Society for the Promotion of Science (KAKENHI) [24614005]
- Grants-in-Aid for Scientific Research [24614005] Funding Source: KAKEN
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Alzheimer's disease (AD) is widely considered to be caused by amyloid-beta peptide (Ab) accumulation in the brain. Ab is excised from amyloid-beta precursor protein through sequential cleavage by beta-secretase 1 (BACE1) and gamma-secretase. Thus, BACE1 inhibition could prevent Ab accumulation. Here, we identified myo-inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited A beta production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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