Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 465, Issue 4, Pages 845-850Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2015.08.098
Keywords
NMDMC; Drosophila; Longevity; Reactive oxygen species; Mitochondrial DNA
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Funding
- future environmental R&D project - Korean Environmental Industry and Technology Institute [RE201206020]
- National Research Foundation (NRF) of Korea - Ministry of Education, Science and Technology (MEST) [2012055351]
- Eco Health Action Project - Korea Ministry of Environment [H112-00135-0011-0]
- Gil Jung Hee Memorial Fund
- Chung-Yang Young Sun Cha Memorial Fund
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NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahYdrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells. However, Nmdmc physiological roles remain unveiled. We found that ubiquitous Nmdmc overexpression enhanced Drosophila lifespan and stress resistance. Interestingly, Nmdmc overexpression in the fat body was sufficient to increase lifespan and tolerance against oxidative stress. In addition, these conditions coincided with significant decreases in the levels of mitochondrial ROS and Hsp22 as well as with a significant increase in the copy number of mitochondrial DNA. These results suggest that Nmdmc overexpression should be beneficial for mitochondrial homeostasis and increasing lifespan. (C) 2015 Elsevier Inc. All rights reserved.
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