Journal
FEBS OPEN BIO
Volume 3, Issue -, Pages 279-284Publisher
WILEY
DOI: 10.1016/j.fob.2013.07.001
Keywords
Local RAS; ATDC5; Hypertrophic differentiation; Angiotensin II type 1 receptor; Angiotensin II type 2 receptor
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (JSPS KAKENHI) [25462389]
- Grants-in-Aid for Scientific Research [25462389] Funding Source: KAKEN
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A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stein cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2. (C) 2013 The Authors, Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved.
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