Journal
FEBS OPEN BIO
Volume 2, Issue -, Pages 217-221Publisher
WILEY
DOI: 10.1016/j.fob.2012.07.007
Keywords
Fourier transform mass spectrometry; Histones; Metabolomics; Saccharopine; Yellow mutation
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Funding
- Scottish Universities Life Sciences Alliance
- UK Biotechnology and Biological Sciences Research Council
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Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y. In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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