Related references
Note: Only part of the references are listed.The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy
Sara Lena Weinhold et al.
BEHAVIOURAL BRAIN RESEARCH (2014)
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial
David Michelson et al.
LANCET NEUROLOGY (2014)
Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Dose Almorexant, an Orexin Receptor Antagonist, in Healthy Elderly Subjects
Petra Hoever et al.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2013)
Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia
Claudia Betschart et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?
Daniel Hoyer et al.
NEUROPEPTIDES (2013)
Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition
Jason M. Uslaner et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
Sarah Wurts Black et al.
SLEEP (2013)
Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia in narcolepsy
Yves Dauvilliers et al.
SLEEP MEDICINE (2013)
Role of orexin in modulating arousal, feeding, and motivation
Natsuko Tsujino et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2013)
The hypocretins and the reward function: what have we learned so far?
Benjamin Boutrel et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2013)
Kinetic properties of dual orexin receptor antagonists at OX1R and OX2R orexin receptors
Gabrielle E. Callander et al.
FRONTIERS IN NEUROSCIENCE (2013)
Distinct effects of IPSU and suvorexant on mouse sleep architecture
Daniel Hoyer et al.
FRONTIERS IN NEUROSCIENCE (2013)
Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
Paul J. Coleman et al.
CHEMMEDCHEM (2012)
Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial
P. Hoever et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia
Paul J. Coleman et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Twelve months of nightly zolpidem does not lead to rebound insomnia or withdrawal symptoms: a prospective placebo-controlled study
Timothy A. Roehrs et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2012)
Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist
Paolo Bettica et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2012)
Orexin receptor antagonism: an ascending multiple-dose study with almorexant
Petra Hoever et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2012)
Orexin receptor antagonism for treatment of insomnia A randomized clinical trial of suvorexant
W. Joseph Herring et al.
NEUROLOGY (2012)
Pharmacological characterization of MK-6096-A dual orexin receptor antagonist for insomnia
Christopher J. Winrow et al.
NEUROPHARMACOLOGY (2012)
Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia
Paolo Bettica et al.
NEUROPSYCHOPHARMACOLOGY (2012)
Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
Stephen R. Morairty et al.
PLOS ONE (2012)
Mechanism for Hypocretin-mediated sleep-to-wake transitions
Matthew E. Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The Dual Orexin Receptor Antagonist Almorexant Induces Sleep and Decreases Orexin-Induced Locomotion by Blocking Orexin 2 Receptors
Geraldine M. Mang et al.
SLEEP (2012)
The Orexin Antagonist SB-649868 Promotes and Maintains Sleep in Men with Primary Insomnia
Paolo Bettica et al.
SLEEP (2012)
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology
Anthony L. Gotter et al.
PHARMACOLOGICAL REVIEWS (2012)
Orexin Receptors: Pharmacology and Therapeutic Opportunities
Thomas E. Scammell et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)
Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors
Marta Morawska et al.
BEHAVIOURAL BRAIN RESEARCH (2011)
Promotion of Sleep by Suvorexant--A Novel Dual Orexin Receptor Antagonist
Christopher J. Winrow et al.
JOURNAL OF NEUROGENETICS (2011)
Differential Roles of Orexin Receptor-1 and-2 in the Regulation of Non-REM and REM Sleep
Michihiro Mieda et al.
JOURNAL OF NEUROSCIENCE (2011)
Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice
Tomomi Tsunematsu et al.
JOURNAL OF NEUROSCIENCE (2011)
Wake-REM sleep transitions for measuring REM sleep disturbance: Comparison between narcolepsy, idiopathic hypersomnia and healthy controls
Sara Lena Weinhold et al.
SLEEP AND BIOLOGICAL RHYTHMS (2011)
Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy
P. C. Baier et al.
SLEEP MEDICINE (2011)
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
Paul J. Coleman et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
The role of hypocretin in driving arousal and goal-oriented behaviors
Benjamin Boutrel et al.
BRAIN RESEARCH (2010)
Orexin Receptor Antagonism, a New Sleep-Promoting Paradigm: An Ascending Single-Dose Study With Almorexant
P. Hoever et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
Christopher D. Cox et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
The brain hypocretins and their receptors: mediators of allostatic arousal
Matthew E. Carter et al.
CURRENT OPINION IN PHARMACOLOGY (2009)
Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience
Christoph Boss et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions
Matthew E. Carter et al.
JOURNAL OF NEUROSCIENCE (2009)
Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
Christine Dugovic et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
FEEDING-ELICITED CATAPLEXY IN OREXIN KNOCKOUT MICE
E. L. Clark et al.
NEUROSCIENCE (2009)
Is Low Histamine a Fundamental Cause of Sleepiness in Narcolepsy and Idiopathic Hypersomnia?
Thomas E. Scammell et al.
SLEEP (2009)
Orexin Receptor Antagonism: A New Principle in Neuroscience
Christoph Boss et al.
CHIMIA (2008)
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
Meng Liu et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Antoine R. Adamantidis et al.
NATURE (2007)
Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans'
Mehdi Tafti
NATURE MEDICINE (2007)
Reply to 'Promotion of sleep by targeting the orexin system in rats, dogs and humans' - Brisbare-Roch et al. reply
Francois Jenck et al.
NATURE MEDICINE (2007)
Promotion of sleep by targeting the orexin system in rats, dogs and humans
Catherine Brisbare-Roch et al.
NATURE MEDICINE (2007)
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Takeshi Sakurai
NATURE REVIEWS NEUROSCIENCE (2007)
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
B Boutrel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Homeostatic, circadian, and emotional regulation of sleep
CB Saper et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Input of orexin/hypocretin by a genetically encoded neurons revealed tracer in mice
T Sakurai et al.
NEURON (2005)
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
M Mieda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Discovering endophenotypes for major depression
G Hasler et al.
NEUROPSYCHOPHARMACOLOGY (2004)
Behavioral state instability in orexin knock-out mice
T Mochizuki et al.
JOURNAL OF NEUROSCIENCE (2004)
Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat
CT Beuckmann et al.
JOURNAL OF NEUROSCIENCE (2004)
Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers
A Germain et al.
BIOLOGICAL PSYCHIATRY (2003)
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice:: Molecular genetic dissection of non-REM and REM sleep regulatory processes
JT Willie et al.
NEURON (2003)
Opportunities in somatostatin research: Biological, chemical and therapeutic aspects
G Weckbecker et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders
E Mignot et al.
NATURE NEUROSCIENCE (2002)
Hypocretin is an early member of the incretin gene family
CE Alvarez et al.
NEUROSCIENCE LETTERS (2002)
The sleep switch: hypothalamic control of sleep and wakefulness
CB Saper et al.
TRENDS IN NEUROSCIENCES (2001)
Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
S Nishino et al.
ANNALS OF NEUROLOGY (2001)
Differential expression of orexin receptors 1 and 2 in the rat brain
JN Marcus et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2001)
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
J Hara et al.
NEURON (2001)
To eat or to sleep? Orexin in the regulation of feeding and wakefulness
JT Willie et al.
ANNUAL REVIEW OF NEUROSCIENCE (2001)
Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting
XY Lu et al.
HORMONES AND BEHAVIOR (2000)
Narcolepsy: genetic predisposition and neuropharmacological mechanisms
S Nishino et al.
SLEEP MEDICINE REVIEWS (2000)
Reduced number of hypocretin neurons in human narcolepsy
TC Thannickal et al.
NEURON (2000)
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
C Peyron et al.
NATURE MEDICINE (2000)
Hypocretin (orexin) deficiency in human narcolepsy
S Nishino et al.
LANCET (2000)