Journal
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
Volume 7, Issue 3, Pages 299-316Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/17512433.2014.907523
Keywords
artemisinin combination therapy; cardiotoxicity; embryotoxicity; hematotoxicity; malaria; nephrotoxicity; neurotoxicity; toxicity
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Artemisinin combination therapy for the treatment of uncomplicated malaria includes artemether plus lumefantrine, artesunate plus amodiaquine, artesunate plus mefloquine, artesunate plus sulfadoxine-pyrimethamine and dihydroartemisinin plus piperaquine. These drugs are safe and efficacious at present. The emergence of artemisinin resistant parasites in SE Asia means that there is a need to optimise drug dosing and investigate novel therapies to maintain the impressive reduction in malaria mortality which has been seen in the past decade.
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