Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 10, Issue 1, Pages 69-75Publisher
SPRINGER
DOI: 10.1007/s12079-015-0315-5
Keywords
Activators; Feedback regulation; Glutamine and inhibitors
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Funding
- Department of Biotechnology (DBT), Government of India
- Department of Science and Technology (DST), Government of India
- Indian Council of Medical Research (ICMR)
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Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, gamma-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.
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