Journal
CHINESE JOURNAL OF CANCER
Volume 33, Issue 11, Pages 556-568Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.014.10170
Keywords
NPC genetics; Epstein-Barr virus; human leukocyte antigen; cell signaling; inflammation
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Funding
- Research Grants Council Area of Excellence [AoE/M-06/08]
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The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen (HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.
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