Journal
CHINESE JOURNAL OF CANCER
Volume 33, Issue 12, Pages 591-597Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.014.10193
Keywords
Epstein-Barr virus; Hodgkin lymphoma; chronic inflammation
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Funding
- Medical Research Council [MR/J002046/1] Funding Source: Medline
- Medical Research Council [MR/J002046/1] Funding Source: researchfish
- National Institute for Health Research [CL-2009-09-003] Funding Source: researchfish
- MRC [MR/J002046/1] Funding Source: UKRI
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Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
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