Journal
CHINESE JOURNAL OF CANCER
Volume 32, Issue 11, Pages 594-603Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.013.10178
Keywords
Cancer genomics; fusion genes; tumorigenesis; therapy; chromosomal instability
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Funding
- National Institutes of Health through MD Anderson Cancer Center [CA016672]
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Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their tumor-specific expression. Originally associated with hemotologic cancers, fusion genes have recently been discovered in a wide array of solid tumors, including sarcomas, carcinomas, and tumors of the central nervous system. Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone. Therefore, the discovery and elucidation of fusion genes in various cancer types may provide more effective therapies in the future for cancer patients.
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