Journal
CHINESE JOURNAL OF CANCER
Volume 32, Issue 7, Pages 363-364Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.5732/cjc.013.10114
Keywords
Targeted therapy; Aurora kinases; PI3K/mTOR signaling; FOXO-FOXM1 axis; MDM2/MDM4-p53 interaction
Categories
Ask authors/readers for more resources
Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available