Journal
CHEMELECTROCHEM
Volume 1, Issue 12, Pages 2082-2088Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/celc.201402250
Keywords
anaerobic measurements; biosensors; glucose detection; oxygen storage; platinum-doped nanoceria
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Funding
- NSF [1200180]
- NIH [R21NS078738-01]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1200180] Funding Source: National Science Foundation
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The use of Pt-doped nanoceria as a new catalytic amplification system for first-generation electrochemical oxidase-based biosensors is described. The catalytic activity and oxygen-rich surface of nanoceria, combined with the high conductivity of noble-metal Pt electrocatalysts, provide enhanced performance characteristics of mediatorless glucose oxidase biosensors for the detection of glucose in oxygen-deficient environments. The Pt-doped nanoceria particles act as both an internal oxygen reservoir to satisfy the oxygen requirement for the enzymatic reaction and a catalytic amplification system for the detection of enzymatically generated H2O2. The biosensor allows detection of glucose in anaerobic conditions with a detection limit of 37.4 mu m. The proposed strategy can be widely applicable to other oxidase-based biosensors that require measurements of their substrates in oxygen-deficient conditions.
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