Journal
CANCER MEDICINE
Volume 3, Issue 3, Pages 731-735Publisher
WILEY
DOI: 10.1002/cam4.211
Keywords
Genetic; risk prediction; SNPs; thyroid cancer
Categories
Funding
- National Science Foundation of China [81001204, 30872958, 81270120]
- Ministry of Science and Technology [2011BAI09B00]
- Ministry of Health [201002007]
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Recently, five thyroid cancer significantly associated genetic variants (rs965513, rs944289, rs116909374, rs966423, and rs2439302) have been discovered and validated in two independent GWAS and numerous case-control studies, which were conducted in different populations. We genotyped the above five single nucleotide polymorphisms (SNPs) in Han Chinese populations and performed thyroid cancer-risk predictions with nine machine learning methods. We found that four SNPs were significantly associated with thyroid cancer in Han Chinese population, while no polymorphism was observed for rs116909374. Small familial relative risks (1.02-1.05) and limited power to predict thyroid cancer (AUCs: 0.54-0.60) indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer.
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