Journal
JOURNAL OF ADVANCED CERAMICS
Volume 4, Issue 2, Pages 118-122Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s40145-015-0139-z
Keywords
carbon; core-shell structure; gadolinia particles; fluorescence; magnetic resonance imaging (MRI) contrast agent
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Funding
- Development Program of Pusan National University
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2014R1A2A1A11051146]
- National Research Foundation of Korea [2014R1A2A1A11051146, 10Z20130000004] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core-shell structure and a narrow size distribution in the range of 261 +/- 27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r(1)) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.
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