Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 118, Issue 3, Pages 84-91Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13813455.2012.685745
Keywords
Adipokines; gene expression; obesity; adiposeregion; microarray
Funding
- 7th Framework of the European Union ADAPT [FP-7-Health-2007-A]
- Novonordisk foundation
- Swedish Research Council
- Marianne and Marcus Wallenbergs' foundation
- Stockholm County Council (ALF)
- Sanofi-Aventis
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Context: Recent secretome analyses suggest that human fat cells secrete hundreds of proteins (adipokines). Objective: We made an overall analysis of their potential functional importance. Materials and methods: A secretome of 347 adipokines was evaluated by in silico analysis of their expression during adipocyte differentiation, regulation by obesity and adipose region. The gene expression in human adipose tissue was investigated in microarray studies using samples from different adipose depots from lean or obese patients. Results: 60% of the adipokines were regulated by obesity and 50% between visceral and subcutaneous adipose region. Eight adipokines, all novel, scored particularly high in the in silico analysis. Among those, four were both regulated by obesity and adipose region, namely WNT1-inducible-signaling pathway protein 2, transmembrane glycoprotein NMB, inter-alpha-trypsin inhibitor heavy chain H5, and complement C4-A. Furthermore, many adipokines were extracellular matrix proteins. Conclusion: Several novel adipokines have potential important functional features warranting in depth analysis.
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