Related references
Note: Only part of the references are listed.Akt-dependent and -independent mechanisms of mTOR regulation in cancer
Regan M. Memmott et al.
CELLULAR SIGNALLING (2009)
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
E. A. Dunlop et al.
CELLULAR SIGNALLING (2009)
mTOR and the control of whole body metabolism
Pazit Polak et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1
Lianqin Zhang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
Mahlon D. Johnson et al.
JOURNAL OF NEURO-ONCOLOGY (2009)
Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
Alfredo Toschi et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice
Andrew M. Miller et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)
Insulin signaling in the pancreatic beta-cell
Ingo B. Leibiger et al.
ANNUAL REVIEW OF NUTRITION (2008)
A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
Erin L. Glynn et al.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2008)
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
Bruno D. Fonseca et al.
BIOCHEMICAL JOURNAL (2008)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
Jingxiang Huang et al.
BIOCHEMICAL JOURNAL (2008)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
Nelson Rhodes et al.
CANCER RESEARCH (2008)
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
Merav Fraenkel et al.
DIABETES (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
EMBO JOURNAL (2008)
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
Margit Rosner et al.
HUMAN MOLECULAR GENETICS (2008)
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Biphasic response of pancreatic β-cell mass to ablation of tuberous sclerosis complex 2 in mice
Yutaka Shigeyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
Feng Hong et al.
MOLECULAR CELL (2008)
The mTOR pathway and its role in human genetic diseases
Margit Rosner et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
Latif Rachdi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
mTOR signaling: RAG GTPases transmit the amino acid signal
Reuben J. Shaw
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
I. M. Jazet et al.
DIABETOLOGIA (2008)
Nutrient sensing and inflammation in metabolic diseases
Goekhan S. Hotamisligil et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury
Fengshan Yu et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
Kathrin Thedieck et al.
PLOS ONE (2007)
Cytoplasmic/nuclear localization of tuberin in different cell lines
M. Rosner et al.
AMINO ACIDS (2007)
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
Kathryn M. Geraghty et al.
BIOCHEMICAL JOURNAL (2007)
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification
D. M. Ouwens et al.
DIABETOLOGIA (2007)
Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity
Hakam Alkhateeb et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor β expression and signaling
So-Yon Woo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
Frederic Tremblay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
Laura R. Pearce et al.
BIOCHEMICAL JOURNAL (2007)
Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
Stephen C. Land et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The proline-rich akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
Noriko Oshiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
Stephen G. Dann et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zhihong Zeng et al.
BLOOD (2007)
PRAS40 deregulates apoptosis in malignant melanoma
SubbaRao V. Madhunapantula et al.
CANCER RESEARCH (2007)
Recent developments in neurofibromatosis type 1
Ming-Jen Lee et al.
CURRENT OPINION IN NEUROLOGY (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
Lobe and Serrate are required for cell survival during early eye development in Drosophila
Amit Singh et al.
DEVELOPMENT (2006)
Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats
Emmani B. M. Nascimento et al.
DIABETES (2006)
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
E. Korsheninnikova et al.
DIABETOLOGIA (2006)
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals
Sang Hoon Ha et al.
CELLULAR SIGNALLING (2006)
Nuclear export of S6K1II is regulated by protein kinase CK2 phosphorylation at Ser-17
Ganna Panasyuk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Qian Yang et al.
GENES & DEVELOPMENT (2006)
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Reuben J. Shaw et al.
NATURE (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
F Furuya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Critical nodes in signalling pathways: insights into insulin action
CM Taniguchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Modulation of proline-rich Akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia
A Saito et al.
STROKE (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
A Tzatsos et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
Sung Hee Um et al.
CELL METABOLISM (2006)
mTOR•RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
RC Hresko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Exploiting the PI3K/AKT pathway for cancer drug discovery
BT Hennessy et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis
B Huang et al.
ACTA PHARMACOLOGICA SINICA (2005)
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
I Ruvinsky et al.
GENES & DEVELOPMENT (2005)
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
F Tremblay et al.
DIABETES (2005)
Akt1 contains a functional leucine-rich nuclear export sequence
M Saji et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells
I Briaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Neuroprotective role of a proline-rich akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor
A Saito et al.
JOURNAL OF NEUROSCIENCE (2004)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
CURRENT BIOLOGY (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at Serine 302
ED Werner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins
SA Beausoleil et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
MN Corradetti et al.
GENES & DEVELOPMENT (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
A Beugnet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
K Bouzakri et al.
DIABETES (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
KS Kovacina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
NESbase version 1.0: a database of nuclear export signals
T la Cour et al.
NUCLEIC ACIDS RESEARCH (2003)
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells
JE Harthill et al.
BIOCHEMICAL JOURNAL (2002)
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
R Loewith et al.
MOLECULAR CELL (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Identification of a conserved motif required for mTOR signaling
SS Schalm et al.
CURRENT BIOLOGY (2002)
WW and SH3 domains, two different scaffolds to recognize proline-rich ligands
MJ Macias et al.
FEBS LETTERS (2002)
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
AR Tee et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel et al.
NATURE (2001)
Serine/threonine phosphorylation of IRS-1 triggers its degradation - Possible regulation by tyrosine phosphorylation
TM Pederson et al.
DIABETES (2001)
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
M Pende et al.
NATURE (2000)
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
JE Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
T Obata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
K Yokogami et al.
CURRENT BIOLOGY (2000)
Share Paper
