Journal
ALLERGOLOGY INTERNATIONAL
Volume 63, Issue 2, Pages 171-180Publisher
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.2332/allergolint.13-RAI-0673
Keywords
allergic rhinitis; aspirin-induced asthma; chronic rhinosinusitis with nasal polyps; IgG4-related disease; periostin
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Funding
- Japan Society for the Promotion of Science and the Ministry of Health, Labour and Welfare of Japan [25462675]
- Grants-in-Aid for Scientific Research [25293224, 25462675] Funding Source: KAKEN
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Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13. Periostin is secreted by fibroblasts and upregulated in the airway epithelia of patients with bronchial asthma; it is considered to contribute to remodeling under this pathological condition. However, despite many studies in diverse research areas, our overall understanding of this intriguing molecule is still inadequate. Here, we integrate the available evidence on periostin expression and its roles in otolaryngological diseases, including allergic rhinitis, chronic rhinosinusitis with nasal polyps, aspirin-induced asthma, organized hematoma, eosinophilic otitis media, and IgG4-related disease. Periostin might be involved as an important structural mediator in pathological processes such as insult and injury, Th2-driven inflammation, extracellular matrix restructuring, fibrosclerosis, tumor angiogenesis, and tissue remodeling.
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