Journal
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
Volume 2, Issue 2, Pages 165-182Publisher
WILEY-BLACKWELL
DOI: 10.1002/wdev.63
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Funding
- NIDCR NIH HHS [K99 DE022059, R01-DE021420, K99-DE022059, R01 DE021420, R01 DE021420-02] Funding Source: Medline
- NIH HHS [DP2-OD007191, DP2 OD007191, DP2 OD007191-01] Funding Source: Medline
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Teeth are unique to vertebrates and have played a central role in their evolution. The molecular pathways and morphogenetic processes involved in tooth development have been the focus of intense investigation over the past few decades, and the tooth is an important model system for many areas of research. Developmental biologists have exploited the clear distinction between the epithelium and the underlying mesenchyme during tooth development to elucidate reciprocal epithelial/mesenchymal interactions during organogenesis. The preservation of teeth in the fossil record makes these organs invaluable for the work of paleontologists, anthropologists, and evolutionary biologists. In addition, with the recent identification and characterization of dental stem cells, teeth have become of interest to the field of regenerative medicine. Here, we review the major research areas and studies in the development and evolution of teeth, including morphogenesis, genetics and signaling, evolution of tooth development, and dental stem cells. (C) 2012 Wiley Periodicals, Inc.
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