4.7 Article

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

J. W. Steele et al.

MOLECULAR PSYCHIATRY (2013)

Article Biochemistry & Molecular Biology

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

J. W. Steele et al.

MOLECULAR PSYCHIATRY (2013)

Article Biochemistry & Molecular Biology

The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon

Thelma R. Cowley et al.

NEUROCHEMICAL RESEARCH (2013)

Article Medicine, Research & Experimental

Dimebon Reduces the Levels of Aggregated Amyloidogenic Protein Forms in Detergent-Insoluble Fractions

A. A. Ustyugov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion

Werner J. Geldenhuys et al.

NEUROCHEMISTRY INTERNATIONAL (2012)

Article Neurosciences

Dimebon Slows Progression of Proteinopathy in γ-Synuclein Transgenic Mice

Sergey O. Bachurin et al.

NEUROTOXICITY RESEARCH (2012)

Article Multidisciplinary Sciences

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

Rachel Tesla et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

Hector De Jesus-Cortes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys

Scott J. Webster et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Neurosciences

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

Jun Wang et al.

MOLECULAR NEURODEGENERATION (2011)

Article Geriatrics & Gerontology

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk

Onofre Combarros et al.

NEUROBIOLOGY OF AGING (2011)

Review Clinical Neurology

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Julie Vignisse et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

Article Clinical Neurology

A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease

Karl Kieburtz et al.

ARCHIVES OF NEUROLOGY (2010)

Article Chemistry, Medicinal

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

Alexandre V. Ivachtchenko et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

Discovery of a Proneurogenic, Neuroprotective Chemical

Andrew A. Pieper et al.

Article Clinical Neurology

From Anti-allergic to Anti-Alzheimer's: Molecular Pharmacology of Dimebon™

I. Okun et al.

CURRENT ALZHEIMER RESEARCH (2010)

Article Biochemistry & Molecular Biology

Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

Xinkun Wang et al.

CURRENT GENOMICS (2010)

Article Food Science & Technology

β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)

T. Herraiz et al.

FOOD AND CHEMICAL TOXICOLOGY (2010)

Editorial Material Biochemistry & Molecular Biology

Mechanism matters

[Anonymous]

NATURE MEDICINE (2010)

Editorial Material Biotechnology & Applied Microbiology

Learning from failure

[Anonymous]

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Pharmacology & Pharmacy

Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities

Herve Schaffhauser et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds

S. O. Bachurin et al.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Biochemistry & Molecular Biology

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

Nora Goeckler et al.

FEBS JOURNAL (2009)

Article Biochemistry & Molecular Biology

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models

Makiko Yamashita et al.

FEBS LETTERS (2009)

Review Cell Biology

A beta aggregation and possible implications in Alzheimer's disease pathogenesis

Prashant R. Bharadwaj et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Article Pharmacology & Pharmacy

Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells

Yoo Jung Yang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Review Chemistry, Medicinal

Multi-target-directed ligands to combat neurodegenerative diseases

Andrea Cavalli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Chemistry, Medicinal

Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease

S. Bastianetto et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

Editorial Material Medicine, General & Internal

Dimebon in Alzheimer's disease: old drug for new indication

Alistair Burns et al.

LANCET (2008)

Article Neurosciences

Evaluation of Dimebon in cellular model of Huntington's disease

Jun Wu et al.

MOLECULAR NEURODEGENERATION (2008)

Review Medicine, General & Internal

Cholinesterase inhibitors in mild cognitive impairment: A systematic review of randomised trials

Roberto Raschetti et al.

PLOS MEDICINE (2007)

Article Clinical Neurology

Dementia with Lewy bodies

M. Omerovic et al.

NERVENARZT (2007)

Article Biochemistry & Molecular Biology

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

JoAnne McLaurin et al.

NATURE MEDICINE (2006)

Review Clinical Neurology

Clinical trials in mild cognitive impairment: lessons for the future

V Jelic et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

Review Pharmacology & Pharmacy

Therapeutic targets: Progress of their exploration and investigation of their characteristics

C. J. Zheng et al.

PHARMACOLOGICAL REVIEWS (2006)

Article Clinical Neurology

Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

P Bubber et al.

ANNALS OF NEUROLOGY (2005)

Review Radiology, Nuclear Medicine & Medical Imaging

Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease - FDG-PET studies in MCI and AD

L Mosconi

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2005)

Article Biochemistry & Molecular Biology

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

SM Cardoso et al.

JOURNAL OF NEUROCHEMISTRY (2004)

Article Medicine, Research & Experimental

Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons

VV Grigor'ev et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2003)

Article Pharmacology & Pharmacy

Role of 5-HT6 receptors in memory formation

A Meneses

DRUG NEWS & PERSPECTIVES (2001)

Review Neurosciences

The physiology of brain histamine

RE Brown et al.

PROGRESS IN NEUROBIOLOGY (2001)

Article Clinical Neurology

Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease

J Thome et al.

JOURNAL OF NEURAL TRANSMISSION (2001)

Review Multidisciplinary Sciences

Cell biology - Autophagy as a regulated pathway of cellular degradation

DJ Klionsky et al.

SCIENCE (2000)

Article Medicine, Research & Experimental

Dimebon improves learning in animals with experimental Alzheimer's disease

NN Lermontova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2000)

Article Biochemistry & Molecular Biology

Low affinity use-dependent NMDA receptor antagonists show promise for clinical development

GC Palmer et al.

AMINO ACIDS (2000)