Journal
TRANSLATIONAL PSYCHIATRY
Volume 1, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/tp.2011.45
Keywords
bipolar disorder; genetic correlation; genome-wide association; polygenic score analysis; personality-major depression
Categories
Funding
- Wellcome Trust [076113, 89061/Z/09/Z, 089062/Z/09/Z]
- Netherlands Scientific Organization Centre for Medical Systems Biology (NWO Genomics) [904-61-090, 904-61-193, 480-04-004, 400-05-717, 912-100-20]
- Neuroscience Campus Amsterdam (NCA)
- EMGO+ Institute
- European Union [EU/WLRT-2001-01254]
- ZonMW [10-000-1002]
- NIMH [RO1 MH059160, R01 MH-079799]
- NESDA
- NTR
- NWO-SPI [56-464-1419]
- Netherlands Organization for Scientific Research (NWO) (ZonMW) [31160008, VENI-016-115-035, 916-76-125]
- Australian National Health and Medical Research Council [241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496675, 496739, 552485, 552498, 613608]
- FP-5 GenomEUtwin Project [QLG2-CT-2002-01254]
- US National Institutes of Health (NIH) [AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206, DA12854, DA019951]
- National Health and Medical Research Council (NHMRC)
- Australian Research Council
- Netherlands Organization for Scientific Research (NWO) [480-05-003]
- Erasmus MC
- Netherlands Genomics Initiative (NGI)
- NIH Genes, Environment and Health Initiative (GEI) [U01 HG004422]
- Gene Environment Association Studies (GENEVA) under GEI
- NIH GEI [U01HG004438]
- National Institute on Alcohol Abuse and Alcoholism
- NIH [AA13320, AA13321, DA12854, HHSN268200782096C, AA07728, AA07580, AA11998]
- NIH from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) [U10AA008401]
- National Institute on Drug Abuse (NIDA)
- NIH from the National Cancer Institute [P01CA89392]
- NIH, National Institute on Aging [NO1-AG-1-2109]
- Academy of Finland [120315, 129287, 1129457, 1216965, 120386, 125876]
- European Science Foundation (EuroSTRESS)
- Signe and Ane Gyllenberg foundation
- Research Into Ageing
- Help the Aged/Age Concern (The Disconnected Mind)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Engineering and Physical Sciences Research Council (EPSRC)
- Economic and Social Research Council (ESRC)
- Medical Research Council (MRC)
- cross-council Lifelong Health and Wellbeing Initiative
- eDIKT initiative
- ECOGENE [205419]
- Estonian Government [SF0180142s08]
- EU
- Estonian Ministry of Science and Education [SF0180029s08]
- Parke-Davis Exchange Fellowship
- [201413 ENGAGE]
- [212111 BBMRI]
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Medical Research Council [G0700704, G1001245, G0700704B] Funding Source: researchfish
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0700704] Funding Source: UKRI
- Academy of Finland (AKA) [129287] Funding Source: Academy of Finland (AKA)
Ask authors/readers for more resources
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13 835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N = 8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N = 6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, similar to 0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other. Translational Psychiatry (2011) 1, e50; doi:10.1038/tp.2011.45; published online 18 October 2011
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