Effects of propylparaben on fecundity and lifespan in Drosophila melanogaster

Parabensare are widely used as preservatives in cosmetics, foods and pharmaceutical products. Although parabens have generally been considered safe, several studies have cautioned that parabens have estrogenic or endocrine-disrupting properties. With the present study, the effects of four concentrations of propylparabens (200, 500, 1000, and 2000 mg L-1) on fecundity, development and the lifespan of Drosophila melanogaster have been investigated. Decreased daily mean egg production was found in all exposure groups. In addition, the 100 mg L-1 treatment significantly shortened egg-to-prepupa time and extended flies lifespan, consistent with a significant reduction in malonyldialdehyde (MDA) level and an increase in superoxide dismutase (SOD) activities. The 200 mg L-1 treatment prolonged egg-to-prepupa time and decreased flies lifespan significantly, being consistent with a significant increase in MDA level and reduction in SOD activities.