Journal
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
Volume 96, Issue 9, Pages 1333-1345Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2015.1005092
Keywords
antibiotics; antifungal compounds; water contamination; multiresidue analysis
Categories
Funding
- [SOP HRD - PERFORM /159/ 1.5/S/138963]
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A number of important rivers of Romania were investigated for pharmaceutical and antifungal residues. In a post target approach analysis, a single-stage, high-resolution mass spectrometry was successfully applied for the screening of 43 pharmaceuticals and fungicides in water, using U-HPLC-Exactive Orbitrap MS at 50,000 full width at half maximum resolution. Detection was based on accurate masses and retention times. The study confirmed the presence of pharmaceuticals and antifungals such as diclofenac, sulfamethoxazole, carbamazepine, trimethoprim, thiabendazole, and clotrimazole, in water. Diclofenac and carbamazepine were the most frequently detected (eight samples); concentrations ranged from 5 to 50 ng L-1. Low concentrations of griseofulvin were detected in the Prut River. Further monitoring studies should be carried out in order to fill the gaps of knowledge concerning the presence of pharmaceutical residues in Romanian water environment and to improve public understanding regarding the environmental risk of pharmaceutical contamination.
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