Journal
SYMMETRY-BASEL
Volume 3, Issue 2, Pages 220-245Publisher
MDPI
DOI: 10.3390/sym3020220
Keywords
Henry; nitroaldol; organocatalysis; enantioselective; nitroalkanes; domino Michael/Henry
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Funding
- Spanish Ministry of Science and Innovation [CTQ2009-09028, CTQ2010-19606]
- Government of Aragon [PI064/09, E-10]
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A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, the Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for the preparation of valuable synthetic intermediates, such as enantioenriched nitro alcohols, which can be further transformed in a number of important nitrogen and oxygen-containing compounds. This area of research is still in expansion and a more complex version of this useful process has recently emerged, the domino Michael/Henry protocol, affording highly functionalized cycles with multiple stereogenic centers.
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