Journal
SYMMETRY-BASEL
Volume 3, Issue 2, Pages 165-170Publisher
MDPI
DOI: 10.3390/sym3020165
Keywords
organocatalyzed reactions; spiro[oxindole-3,4 '-4 ' H-pyrane]; Brevicolline; Cinchonidine; Cinchonine
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Funding
- Royal Society International Joint Project [JP090309]
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The paper presents an application of the asymmetry approach to spirooxindoles via Brevicolline, Cinchonidine or Cinchonine catalyzed one-pot multicomponent synthesis. Brevicolline, in comparison with Cinchonidine or Cinchonine, catalyzes the reaction of isatins, acetylacetone/ethyl 3-oxobutanoate and malononitrile, with the formation of spiro[oxindole-3,4'-4'H-pirane] derivatives in an optically active form in very good to excellent yields.
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