Journal
PATHOGENS AND DISEASE
Volume 70, Issue 3, Pages 231-239Publisher
OXFORD UNIV PRESS
DOI: 10.1111/2049-632X.12141
Keywords
Staphylococcus aureus; anti-biofilm agents; quorum sensing
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Staphylococcus aureus is a Gram-positive pathogen that causes potentially life-threatening nosocomial- and community-acquired infections, such as osteomyelitis and endocarditis. Staphylococcus aureus has the ability to form multicellular, surface-adherent communities called biofilms, which enables it to survive in various sources of stress, including antibiotics, nutrient limitations, heat shock, and immune responses. Biofilm-forming capacity is now recognized as an important virulence determinant in the development of staphylococcal device-related infections. In light of the projected increase in the numbers of elderly patients who will require semi-permanent indwelling medical devices such as artificial knees and hips, we can anticipate an expanded need for new agents and treatment options to manage biofilm-associated infections in an expanding at-risk population. With better understanding of staphylococcal biofilm formation and growth, novel strategies that target biofilm-associated infections caused by S.aureus have recently been described and seem promising as future anti-biofilm therapies.
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