Journal
NUCLEUS
Volume 5, Issue 3, Pages 224-236Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.29347
Keywords
transcription; RNA Polymerase II; Serine 2; Bur1; Ctk1; Cdk9; Cdk12; P-TEFb; elongation; C. elegans
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Funding
- NIGMS NIH HHS [R01 GM101040] Funding Source: Medline
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The transition between initiation and productive elongation during RNA Polymerase II (Pol II) transcription is a well-appreciated point of regulation across many eukaryotes. Elongating Pol II is modified by phosphorylation of serine 2 (Ser2) on its carboxy terminal domain (CTD) by two kinases, Bur1/Ctk1 in yeast and Cdk9/Cdk12 in metazoans. Here, we discuss the roles and regulation of these kinases and their relationship to Pol II elongation control, and focus on recent data from work in C. elegans that point out gaps in our current understand of transcription elongation.
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