Journal
NUCLEUS
Volume 5, Issue 2, Pages 124-130Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.28825
Keywords
Lamin B1; nuclear organization; LADs; single cell; Lamin A; chromatin domains; BAF
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Funding
- EMBO Long-Term Fellowship
- NWO-ALW VENI
- NWO-ALW VICI
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The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). Recently, a new live-cell imaging approach demonstrated directly that LAD-NL interactions are dynamic and in part stochastic. Here we discuss implications of these new findings and introduce Lamin A and BAF as potential modulators of stochastic LAD positioning.
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