Journal
BIO-MEDICAL MATERIALS AND ENGINEERING
Volume 26, Issue -, Pages S911-S916Publisher
IOS PRESS
DOI: 10.3233/BME-151384
Keywords
Nanobubbles; ultrasound-triggered phase transition; multimodal contrast agent; ultrasound imaging; magnetic resonance imaging; fluorescence imaging
Funding
- National Science Foundation of China (NSFC) [31170960, 31470968]
- National High Technology Research and Development Program of China (863 Program) [2012AA022704]
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Fluorescence dye DiR and superparamagnetic iron oxide nanoparticles (SPIONs) embedded in PEG-PLGA nanobubbles (DiR-SPIO-NBs) were produced using double emulsion method on a membrane of Shirasu porous glass (SPG). The nanobubbles encapsulated with DiR and SPIONs had a liquid core (perfluoropentane) and a PEG-PLGA shell. DiR-SPIO-NBs showed biocompatibility based on MTT cytotoxicity and hemolysis studies. The PFP encapsulated in the nanobubbles experienced phase transition under ultrasonic irradation. Nanobubbles dispersed well in saline over 3 months, and the relaxivity was 127.9 mM(-1)s(-1), suggesting that it could be used as a contrast agent in MRI. The MR and fluorescence images in vivo demonstrated that the signal intensity in the spleen and liver was significantly enhanced with the treatment of nanobubbles. In addition, results of ultrasound images suggested that the nanobubbles had persistent contrast ability. In conclusion, nanobubbles could be utilized as an US/MRI/fluorescence contrast agent.
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