Journal
NUCLEUS
Volume 3, Issue 3, Pages 251-255Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.20391
Keywords
Rif1; silencing; SIRS; telomeres; chromosomes
Categories
Funding
- National Institutes of Health [GM51492, GM56890]
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Many proteins are post-translationally modified by lipid moieties such as palmitoyl or prenyl (e. g., farnesyl) groups, creating functional proteolipids. Lipid modifications share the property of increasing a protein's hydrophobicity and thus the propensity of that protein to associate with a membrane. These modifications are used to control the localization and activity of membrane-associated proteins. A well-recognized paradigm is farnesylation of the Ras GTPase that helps target this critical signaling protein to the plasma membrane.(1)
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