Journal
NUCLEUS
Volume 2, Issue 6, Pages 523-526Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.2.6.16117
Keywords
RanGAP1; RanGTP gradient; nuclear envelope breakdown; nuclear pore complex; open mitosis; closed mitosis; meiosis
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Funding
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23247003, 20114001] Funding Source: KAKEN
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During mitosis in higher eukaryotic cells, nuclear envelope breakdown (NEBD) occurs and leads to the disassembly of the nuclear membrane and nuclear pore complexes (NPC). This brings about a mixing of nuclear and cytoplasmic macromolecules (open mitosis). On the other hand, in many fungi, mitosis occurs without NEBD (closed mitosis). In a recent study, we reported a novel phenomenon in a closed mitosis organism, Schizosaccharomyces pombe: mixing of nuclear and cytoplasmic proteins occurred in meiosis without breakdown of the nuclear membrane or disassembly of nuclear pore complexes. We designated this event virtual nuclear envelope breakdown (V-NEBD). The key event in V-NEBD is nuclear translocation of Rna1, a RanGAP1 homologue in S. pombe. This leads to collapse of the Ran-GTP gradient across the nuclear envelope (NE) and occurs coincidently with V-NEBD. Thus, the barrier function of the NE can be abated without its physical breakdown through modulation of the Ran-GTP gradient.
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