Journal
NUCLEUS
Volume 2, Issue 5, Pages 332-338Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.2.5.17707
Keywords
heterochromatin; non-coding RNA; development; chromatin; pericentromere
Categories
Funding
- la Ligue Nationale contre le Cancer (Equipe labellisee Ligue)
- PIC Programs
- European Commission Network of Excellence EpiGeneSys [HEALTH-F4-2010-257082]
- European Commission ITN [FP7-PEOPLE-2007-215148, FP7-PEOPLE-2008-238176]
- ERC [2009-AdG_20090506]
- European Commission [FP7_HEALTH-2010-259743]
- ANR [ANR-09-BLAN-0257-01, ANR-10-BLAN-1326-03]
- INCa
- Agence Nationale de la Recherche (ANR) [ANR-10-BLAN-1326] Funding Source: Agence Nationale de la Recherche (ANR)
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Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at the pericentromere is a conserved feature throughout evolution, which impacts genome stability. Here, we will summarize recent advances in our understanding of the dynamics of mouse pericentric heterochromatin during the cell cycle and development. Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms.
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