Journal
NUCLEUS
Volume 1, Issue 6, Pages 460-471Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.1.6.13513
Keywords
laminopathies; lamin A; protein interactions; chromatin interactions; mass spectrometry; oneSTrEP; immunoprecipitation; affinity purification; chromatin immunoprecipitation; DamID
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Funding
- Intramural NIH HHS [ZIA BC010309-11] Funding Source: Medline
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The nuclear envelope and the lamina define the nuclear periphery and are implicated in many nuclear processes including chromatin organization, transcription and DNA replication. Mutations in lamin A proteins, major components of the lamina, interfere with these functions and cause a set of phenotypically diverse diseases referred to as laminopathies. The phenotypic diversity of laminopathies is thought to be the result of alterations in specific protein-and chromatin interactions due to lamin A mutations. Systematic identification of lamin A-protein and -chromatin interactions will be critical to uncover the molecular etiology of laminopathies. Here we summarize and critically discuss recent technology to analyze lamina-protein and-chromatin interactions.
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