Journal
NEURAL PLASTICITY
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/945034
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Funding
- National Science Foundation [DMS-0714589]
- NIH [R01 GM100474-01]
- Joyce and Les Goodman scholarship
- New Jersey Commission on Spinal Cord Research [CSCR13IRG006]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM100474] Funding Source: NIH RePORTER
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Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Macrophages are heterogeneous cells with extensive functional plasticity and have the capacity to switch phenotypes by factors present in the inflammatory microenvironment of the injured spinal cord. This review will discuss the role of different polarized macrophages and the potential effect of macrophage-based therapies for SCI.
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