3.8 Article

Intestinal absorption and biological effects of orally administered amorphous silica particles

Journal

NANOSCALE RESEARCH LETTERS
Volume 9, Issue -, Pages -

Publisher

SPRINGER
DOI: 10.1186/1556-276X-9-532

Keywords

Biological effects; Everted gut sac method; Intestinal absorption; Silica nanoparticles

Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
  2. Japan Society for the Promotion of Science (JSPS)
  3. Knowledge Cluster Initiative (MEXT)
  4. Health Labour Sciences Research Grants from the Ministry of Health, Labour, and Welfare of Japan (MHLW)
  5. Global Environment Research Fund from the Ministry of the Environment of Japan
  6. Food Safety Commission, Japan
  7. Research Foundation for Pharmaceutical Sciences
  8. Japan Food Chemical Research Foundation
  9. Grants-in-Aid for Scientific Research [25670075] Funding Source: KAKEN

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Although amorphous silica nanoparticles are widely used in the production of food products (e.g., as anticaking agents), there is little information available about their absorption and biological effects after oral exposure. Here, we examined the in vitro intestinal absorption and in vivo biological effects in mice of orally administered amorphous silica particles with diameters of 70, 300, and 1,000 nm (nSP70, mSP300, and mSP1000, respectively) and of nSP70 that had been surface-modified with carboxyl or amine groups (nSP70-C and nSP70-N, respectively). Analysis of intestinal absorption by means of the everted gut sac method combined with an inductively coupled plasma optical emission spectrometer showed that the intestinal absorption of nSP70-C was significantly greater than that of nSP70. The absorption of nSP70-N tended to be greater than that of nSP70; however, the results were not statistically significant. Our results indicate that silica nanoparticles can be absorbed through the intestine and that particle diameter and surface properties are major determinants of the degree of absorption. We also examined the biological effects of the silica particles after 28-day oral exposure in mice. Hematological, histopathological, and biochemical analyses showed no significant differences between control mice and mice treated with the silica particles, suggesting that the silica nanoparticles evaluated in this study are safe for use in food production.

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