3.8 Article

Efficient CD44-targeted magnetic resonance imaging (MRI) of breast cancer cells using hyaluronic acid (HA)-modified MnFe2O4 nanocrystals

Journal

NANOSCALE RESEARCH LETTERS
Volume 8, Issue -, Pages 1-9

Publisher

SPRINGER
DOI: 10.1186/1556-276X-8-149

Keywords

Colloidal nanoparticles; Nanomedicine; Nanobioimaging; Hyaluronic acid; Magnetic resonance imaging

Funding

  1. Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea [A085136]
  2. National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea [1020340]
  3. National Research Foundation of Korea (NRF)
  4. Korean government (MEST) [2011-0018360]
  5. Korea Health Promotion Institute [1020340] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Targeted molecular imaging with hyaluronic acid (HA) has been highlighted in the diagnosis and treatment of CD44-overexpressing cancer. CD44, a receptor for HA, is closely related to the growth of cancer including proliferation, metastasis, invasion, and angiogenesis. For the efficient detection of CD44, we fabricated a few kinds of HA-modified MnFe2O4 nanocrystals (MNCs) to serve as specific magnetic resonance (MR) contrast agents (HA-MRCAs) and compared physicochemical properties, biocompatibility, and the CD44 targeting efficiency. Hydrophobic MNCs were efficiently phase-transferred using aminated polysorbate 80 (P80) synthesized by introducing spermine molecules on the hydroxyl groups of P80. Subsequently, a few kinds of HA-MRCAs were fabricated, conjugating different ratios of HA on the equal amount of phase-transferred MNCs. The optimized conjugation ratio of HA against magnetic content was identified to exhibit not only effective CD44 finding ability but also high cell viability through in vitro experiments. The results of this study demonstrate that the suggested HA-MRCA shows strong potential to be used for accurate tumor diagnosis.

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