Journal
NANOSCALE RESEARCH LETTERS
Volume 7, Issue -, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/1556-276X-7-623
Keywords
Gold nanoparticles; Green synthesis; Antibacterial activity; Propidium iodide; Outer membrane vesicles
Funding
- Department of Chemistry, Advanced Materials Institute, Ogden College of Science and Engineering, Office of Sponsored Programs at Western Kentucky University
- National Center for Research Resources [5P20RR016481-12]
- National Institute of General Medical Sciences from the National Institutes of Health [8 P20 GM103436-12]
- National Science Foundation Research Experience for Undergraduates (REU) [EAR-1004655]
Ask authors/readers for more resources
The antimicrobial properties of dextrose-encapsulated gold nanoparticles (dGNPs) with average diameters of 25, 60, and 120 nm (+/- 5) and synthesized by green chemistry principles were investigated against both Gram-negative and Gram-positive bacteria. Studies were performed involving the effect of dGNPs on the growth, morphology, and ultrastructural properties of bacteria. dGNPs were found to have significant dose-dependent antibacterial activity which was also proportional to their size. Experiments revealed the dGNPs to be bacteriostatic as well as bactericidal. The dGNPs exhibited their bactericidal action by disrupting the bacterial cell membrane which leads to the leakage of cytoplasmic content. The overall outcome of this study suggests that green-synthesized dGNPs hold promise as a potent antibacterial agent against a wide range of disease-causing bacteria by preventing and controlling possible infections or diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
