Journal
NANOSCALE RESEARCH LETTERS
Volume 7, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1186/1556-276X-7-452
Keywords
magnetoliposomes; magnetic nanoparticles; inflammation; biodistribution; external magnetic field
Funding
- Spanish Ministerio de Ciencia e Innovacion (MICINN) [MAT2009-13155-C04-03]
Ask authors/readers for more resources
This study looked at the effect of an external magnet on the biodistribution of magnetoliposomes intravenously administrated in mice (8 mg iron/kg) with and without induced acute inflammation. Our results showed that due to enhanced vascular permeability, magnetoliposomes accumulated at the site of inflammation in the absence of an external magnetic field, but the amount of iron present increased under the effect of a magnet located at the inflammation zone. This increase was dependent on the time (20 or 60 min) of exposure of the external magnetic field. It was also observed that the presence of the magnet was associated with lower amounts of iron in the liver, spleen, and plasma than was found in mice in which a magnet had not been applied. The results of this study confirm that it is possible to target drugs encapsulated in magnetic particles by means of an external magnet.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available