Journal
NANOSCALE RESEARCH LETTERS
Volume 6, Issue -, Pages 1-7Publisher
SPRINGEROPEN
DOI: 10.1186/1556-276X-6-591
Keywords
quantum dots; gamma-radiation; chitosan; ZnS; ZnS:Mn2+; biocompatible
Funding
- National Natural Science Foundation of China [11105073, 81101146, 81071256]
- China Postdoctoral Science Foundation [20100471338]
- Natural Science Foundation of Jiangsu Province [BK2008400, BK2011739, BK2011738]
- NUAA [NS2010152]
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Biocompatible chitosan-coated ZnS quantum dots [CS-ZnS QDs] and chitosan-coated ZnS:Mn2+ quantum dots [CS-ZnS:Mn2+ QDs] were successfully fabricated via a convenient one-step gamma-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS:Mn2+ QDs showed low cytotoxicity and good biocompatibility, which offered possibilities for further biomedical applications. Moreover, this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan. PACS: 81.07.Ta; 78.67.Hc; 82.35.Np; 87.85.Rs.
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