Journal
FRONTIERS OF MEDICINE
Volume 9, Issue 1, Pages 10-19Publisher
SPRINGER
DOI: 10.1007/s11684-015-0388-9
Keywords
IL-17; Th17 cells; ROR gamma t; autoimmune diseases; posttranslational modification; inhibitors
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Funding
- National Basic Research Program of China [2014CB541803, 2014CB541903]
- National Natural Science Foundation of China [81330072, 31370863, 31200647, 81271835]
- National Science and Technology Major Project [2012ZX10002007-003]
- STCSM project [14JC1406100]
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Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, inflammatory bowel disease, and multiple sclerosis.
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