Journal
FRONTIERS IN IMMUNOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00480
Keywords
spleen; macrophages; phagocytosis; pattern-recognition receptors; tissue remodeling
Categories
Funding
- Sao Paulo Research Foundation (FAPESP) [2013/07140-2, 2014/00810-5]
- National Council for Scientific and Technological Development (CNPq) [303676/2014-0, 448765/2014-4]
Ask authors/readers for more resources
The spleen is one of the major immunological sites for maintaining blood homeostasis. Previous studies showed that heterogeneous splenic macrophage populations contribute in complimentary ways to control blood-borne infections and induce effective immune responses. Marginal metallophilic macrophages (MMM Phi s) and marginal zone macrophages (MZM Phi s) are cells with great ability to internalize blood-borne pathogens such as virus or bacteria. Their localization adjacent to T- and B-cell-rich splenic areas favors the rapid contact between these macrophages and cells from adaptive immunity. Indeed, MMM Phi s and MZM Phi s are considered important bridges between innate and adaptive immunity. Although red pulp macrophages (RpM Phi s) are mainly considered scavengers for senescent erythrocytes, several data indicate a role for RpM Phi s in control of infections such as blood-stage malaria as well as in the induction of innate and adaptive immunity. Here, we review current data on how different macrophage subsets recognize and help eliminate blood-borne pathogens, and, in turn, how the inflammatory microenvironment in different phases of infection (acute, chronic, and after pathogen clearance) influences macrophage function and survival.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available