Journal
JAMA NEUROLOGY
Volume 71, Issue 2, Pages 233-236Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/jamaneurol.2013.5026
Keywords
-
Categories
Funding
- American Heart Association [13POST16580004]
- National Heart, Lung, and Blood Institute [R01-HL114477, R01-HL095629]
Ask authors/readers for more resources
Innate immune cells are critically involved in ischemic complications of atherosclerosis. While new insight emerged on the origin and role of leukocytes in steady state, the knowledge about myeloid cells' sources, functions, and fate after stroke is limited. In our review, we highlight open questions in this important area while examining potential parallels in the immune response after stroke and myocardial infarction. We stress the need to better understand systemic interactions between ischemic tissue, immunity, and hematopoiesis, as turnover of leukocytes in inflammatory sites can be rapid, and cell production and supply may serve as future therapeutic targets to modulate inflammation in the vessel wall, brain, and heart.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available