Journal
JAMA NEUROLOGY
Volume 70, Issue 3, Pages 383-389Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/jamaneurol.2013.603
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Funding
- NCRR NIH HHS [M01 RR000645, UL1 RR024156] Funding Source: Medline
- NIA NIH HHS [R01 AG037212, P01 AG007232, K23 AG034550, R01 AG040093, P50 AG008702] Funding Source: Medline
- NIMHD NIH HHS [P60 MD000206] Funding Source: Medline
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Objective: To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort. Design and Setting: A cohort study was conducted in Northern Manhattan, New York, New York. Participants: A total of 2160 community-dwelling Medicare recipients aged 65 years or older were included in the study. Methods: Depression was assessed using the 10-item version of the Center for Epidemiological Studies Depression scale (CES-D) and defined by a CES-D score of 4 or more. We used logistic regression for cross-sectional association analyses and proportional hazards regression for longitudinal analyses. Main Outcome Measures: Mild cognitive impairment dementia, and progression from MCI to dementia were the main outcome measures. We also used subcategories of MCI (amnestic and nonamnestic), and dementia (probable Alzheimer disease and vascular dementia, including possible Alzheimer disease with stroke). Results: Baseline depression was associated with prevalent MCI (odds ratio, 1.4; 95% CI, 1.1-1.9) and dementia (2.2; 1.6-3.1). Baseline depression was associated with an increased risk of incident dementia (hazard ratio [HR], 1.7; 95% CI, 1.2-2.3) but not with incident MCI (0.9; 0.7-1.2). Persons with MCI and coexisting depression at baseline had a higher risk of progression to dementia (HR, 2.0; 95% CI, 1.2-3.4), especially vascular dementia (4.3; 1.1-17.0), but not Alzheimer disease (1.9; 1.0-3.6). Conclusion: The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it. JAMA Neurol. 2013;70(3):383-389. Published online December 31, 2012. doi:10.1001/jamaneurol.2013.603
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